The purpose of this study is to determine the effect of perceived organizational support and structural and psychological empowerment on entrepreneurship. Based on the relation between variables in this research, an analysis was also conducted on the predictive power of perceived organizational support and structural and psychological empowerment on the level of entrepreneurship in addition to the mediator role of structural and psychological empowerment between perceived organizational support and entrepreneurship. As a descriptive study modeled as relational design, this analysis was implemented among 579 teachers employed in a number of elementary, secondary and high schools of (Kdz. Ereğli) a district of Western Black Sea Region in Turkey. In the study, perceived organizational support, psychological empowerment, structural empowerment and entrepreneurship scales were administered. Arithmetic means, standard deviation, Anova, Correlation Analysis, Multiple Regression Analysis and Structural Equation Model-Path Analysis were harnessed in the analysis of collected data. Significantly positive relations were measured between perceived organizational support, structural and psychological empowerment and entrepreneurship levels. It was identified that perceived organizational support and structural and psychological empowerment were significant predictors of entrepreneurship. Additionally it was manifested that structural and psychological empowerment played a partial mediator role between perceived organizational support and entrepreneurship.